Tesamorelin dosage chart
10 mg Vial
Tesamorelin is dosed at 1 mg–2 mg daily by subcutaneous injection in educational protocols, typically at night. A 10 mg vial reconstituted with bacteriostatic water yields about 3.33 mg/mL. This information is for research and educational use only.
- Reconstitute
- Add 3.0 mL bacteriostatic water per 10 mg vial → ~3.33 mg/mL concentration.
- Standard daily dose
- 2 mg (2000 mcg) once daily subcutaneously (FDA-approved protocol).
- Easy measuring
- At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U-100 insulin syringe.
- Storage
- Lyophilized: refrigerate at 2–8 °C (35.6–46.4 °F); reconstituted: refrigerate and use within 7 days with bacteriostatic water.
Dosing schedule
| Week | Daily Dose (mg / mcg) | Units (per injection) (mL) |
|---|---|---|
| Week 1 | 1 mg / 1000 mcg | 30 units (0.30 mL) |
| Weeks 2–12+ | 2 mg / 2000 mcg | 60 units (0.60 mL) |
Reconstitution steps
- 1Draw 3.0 mL bacteriostatic water with a sterile syringe.
- 2Inject slowly down the vial wall; avoid foaming.
- 3Gently swirl until dissolved (do not shake).
- 4Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
- 5Use within 7 days when reconstituted with bacteriostatic water.
Important Notes
Practical considerations for consistency and safety.
- Use new sterile insulin syringes for each injection; dispose in a sharps container.
- Rotate injection sites (abdomen at least 2 inches from navel, thighs, upper arms) to reduce local irritation.
- Inject slowly; wait a few seconds before withdrawing the needle.
- Monitor IGF-1 levels periodically due to potent GH stimulation; observe blood glucose in diabetic patients.
- Document daily dose and site rotation to maintain consistency.
How This Works
Tesamorelin mimics natural human GHRH by binding to pituitary GHRH receptors, triggering pulsatile growth hormone secretion and consequent IGF-1 elevation. This cascade promotes lipolysis (fat breakdown), protein synthesis, and favorable metabolic shifts. In HIV-associated lipodystrophy, daily tesamorelin significantly reduces visceral adipose tissue and improves lipid profiles over 6–12 months. Research also explores tesamorelin’s potential to reduce liver fat in NAFLD patients and enhance cognitive function in older adults by restoring age-related GH/IGF-1 declines.
Potential Benefits & Side Effects
Observations from clinical trials and FDA-approved use.
- Significant reduction in visceral adipose tissue (measurable after 3–6 months).
- Improved lipid profiles and potential liver fat reduction in NAFLD.
- Enhanced cognitive function in older adults (research ongoing).
- Well-tolerated with maintained benefits during continuous use up to 52 weeks.
- Injection-site reactions: Mild redness, itching, pain, or bruising at injection area.
- Musculoskeletal symptoms: Joint pain (arthralgia), muscle aches, peripheral edema (mild swelling).
- Carpal tunnel symptoms: Occasional tingling or numbness in extremities (dose-dependent, reversible).
- Metabolic monitoring: IGF-1 elevation requires monitoring; small increases in HbA1c observed in some patients.
- Active malignancies (tesamorelin may accelerate growth of latent tumors).
- Pregnancy (may harm fetus).
- Known hypersensitivity to tesamorelin or mannitol.
Lifestyle Factors
Complementary strategies for optimal outcomes.
- Combine with a balanced, protein-forward diet to support GH/IGF-1 anabolic effects.
- Integrate resistance training and aerobic activity to maximize fat loss and metabolic benefits.
- Prioritize 7–9 hours of quality sleep to optimize natural GH pulsatility.
- Manage stress through mindfulness or relaxation techniques to support adherence and recovery.
Injection Technique
Subcutaneous injection best practices from clinical guidelines.
- Clean the vial stopper and skin with alcohol swabs; allow to air-dry completely.
- Pinch a skinfold at the injection site (abdomen preferred, at least 2 inches from navel).
- Insert the needle at 90° (if adequate subcutaneous fat) or 45° (if lean).
- Release the pinch, then inject slowly; wait 2–3 seconds before withdrawing.
- Rotate injection sites systematically (left/right abdomen, thighs, upper arms) to prevent lipohypertrophy.
- Dispose of used syringes immediately in a puncture-proof sharps container.
important-note
This content is intended for therapeutic educational purposes only and does not constitute medical advice, diagnosis, or treatment. Tesamorelin is a prescription medication (FDA-approved as Egrifta®) for HIV-related lipodystrophy. Any off-label use should comply with applicable laws and be conducted under appropriate medical supervision. Consult a qualified medical professional before considering any therapeutic use of tesamorelin.
Tesamorelin dosage FAQs
How much bacteriostatic water do you use to reconstitute Tesamorelin?
Add 3.0 mL bacteriostatic water per 10 mg vial → ~3.33 mg/mL concentration. for a 10 mg Vial vial. Add the water slowly against the inside wall of the vial and swirl — never shake — until the powder fully dissolves.
What is a typical Tesamorelin dose?
Standard daily dose: 2 mg (2000 mcg) once daily subcutaneously (FDA-approved protocol).. Figures are research reference values only.
What does the Tesamorelin dosing schedule look like?
Week 1 — 1 mg / 1000 mcg — 30 units (0.30 mL); Weeks 2–12+ — 2 mg / 2000 mcg — 60 units (0.60 mL). The full table above lists every step with matching syringe units.
What are the mixing steps for Tesamorelin?
Draw 3.0 mL bacteriostatic water with a sterile syringe. Inject slowly down the vial wall; avoid foaming. Gently swirl until dissolved (do not shake).
How should reconstituted Tesamorelin be stored?
Storage: Lyophilized: refrigerate at 2–8 °C (35.6–46.4 °F); reconstituted: refrigerate and use within 7 days with bacteriostatic water..
How many insulin syringe units equal a Tesamorelin dose?
Units depend on the water volume you used. Divide your target dose by the vial concentration to get millilitres, then multiply by 100 — 1 unit on a U-100 insulin syringe is 0.01 mL. The Spartan Peptides reconstitution calculator does this conversion for you.
Is Tesamorelin approved for human use?
No. Tesamorelin is sold and referenced strictly as a research chemical. Nothing on this page is medical advice and the material is not for human consumption.
Educational and research information only. Not medical advice, not for human consumption. Values are reference figures — always verify your own math with the reconstitution calculator.
On any insulin syringe, 1 unit = 0.01 mL, so unit counts above hold across brands.