Adipotide dosage chart
10 mg Vial
Adipotide is dosed at 250 mcg–1 mg daily via subcutaneous injection in educational protocols. A 10 mg vial reconstituted with bacteriostatic water yields about 3.33 mg/mL. This information is for research and educational use only.
- Reconstitute
- Add 3.0 mL bacteriostatic water (max vial capacity) → ~3.33 mg/mL concentration.
- Starting dose
- 250 mcg once daily; gradual escalation by 250 mcg every 2 weeks as tolerated.
- Easy measuring
- At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.33 mcg on a U‑100 insulin syringe.
- Storage
- Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.
- Injection frequency
- Once daily — 5 days on, 2 days off (dose Mon–Fri, rest Sat–Sun).
- Dosing schedule
- 5 days on / 2 days off: dose Monday through Friday, then take Saturday and Sunday off. That is 5 dosing days per week.
Dosing schedule
| Week | Daily Dose (mcg) | Units (per injection) (mL) |
|---|---|---|
| Weeks 1–2 | 250 mcg | 7.5 units (0.08 mL) |
| Weeks 3–4 | 500 mcg | 15 units (0.15 mL) |
| Weeks 5–6 | 750 mcg | 22.5 units (0.23 mL) |
| Weeks 7–8 | 1000 mcg (1.0 mg) | 30 units (0.30 mL) |
Reconstitution steps
- 1Draw 3.0 mL bacteriostatic water with a sterile syringe.
- 2Inject slowly down the vial wall; avoid foaming.
- 3Gently swirl/roll until dissolved (do not shake).
- 4Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Dosing Cycle & Timing
This protocol runs on a 5 days on / 2 days off cycle.
- Cycle: 5 days on, 2 days off — dose Monday through Friday and rest on the weekend.
- 5 dosing days per week; the 2 off days help limit receptor desensitisation and give injection sites time to recover.
- Keep the dose time consistent on dosing days.
- If a weekday dose is missed, take it the same day if possible — do not dose on an off day to catch up.
- Weekly totals in the supplies and shopping lists are calculated on 5 dosing days, not 7.
Important Notes
Practical considerations for consistency and safety.
- Use new sterile insulin syringes; dispose in a sharps container.
- Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation.
- Inject slowly; wait a few seconds before withdrawing the needle.
- Document daily dose and site rotation to maintain consistency.
- Safety consideration: Clinical development was discontinued due to safety concerns including reversible kidney toxicity at higher doses. This protocol is for educational purposes only.
How This Works
Adipotide is a peptidomimetic compound designed to selectively target blood vessels within white adipose tissue by binding to prohibitin‑1 on the vascular endothelium. Once bound, it delivers a pro‑apoptotic sequence that triggers vessel destruction, cutting off the blood supply to fat cells and causing them to undergo apoptosis and be metabolized. Preclinical studies in obese rodents demonstrated approximately 30% body weight reduction, and obese primates showed about 11% weight loss after 4 weeks of treatment. A first‑in‑human Phase 1 trial was initiated in obese cancer patients, but further clinical development was discontinued due to strategic and safety reasons, including reversible renal effects observed at higher doses.
Potential Benefits & Side Effects
Observations from preclinical literature and limited human data.
- Preclinical studies showed notable targeted fat mass reduction (up to 30% body weight in rodents, ~11% in primates over 4 weeks).
- Mechanism specifically targets adipose tissue vasculature, sparing other tissues in preclinical models.
- Safety concerns: Clinical development was discontinued due to safety issues; reversible kidney toxicity was dose‑dependent in preclinical studies.
- Mild injection‑site reactions (redness, swelling) may occur with subcutaneous administration.
- Limited human data: Only Phase 1 trial data available; long‑term safety profile in humans is unknown.
Lifestyle Factors
Complementary strategies for best outcomes.
- Pair with a balanced, protein‑forward diet tailored to energy needs.
- Combine resistance training and aerobic activity to reinforce metabolic adaptations.
- Prioritize sleep and stress management to support adherence and recovery.
- Monitor kidney function if extending beyond initial 4‑week cycle due to preclinical observations of renal effects.
Injection Technique
General subcutaneous guidance from clinical best‑practice resources.
- Clean the vial stopper and skin with alcohol; allow to dry fully.
- Pinch a skinfold; insert the needle at 45–90° into subcutaneous tissue (45° if limited subcutaneous fat, 90° if ample tissue).
- Do not aspirate for subcutaneous injections; inject slowly and steadily.
- Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy and local irritation.
- Wait a moment before withdrawing the needle; apply gentle pressure but do not rub the injection site.
Important Note
This content is intended for therapeutic educational purposes only and does not constitute medical advice, diagnosis, or treatment. Adipotide’s clinical development was discontinued due to safety concerns. This information is for research purposes only. Not for human consumption.
Supplies needed
Plan covers the full 8-week protocol at the lowest listed starting dose: 0.25 mg per dose, 5 days on / 2 days off (40 administrations in total), using 10 mg vials. After mixing with 3 mL, the concentration is 3.33 mg/mL and each dose requires 0.08 mL total.
Adipotide vials (10 mg each)
Vials are rounded up only after calculating the whole protocol: ceil(10 ÷ 10) = 1. Usable peptide remaining in an opened vial carries forward to the next dose.
- Full protocol (8 weeks)
- 1 vial (10 mg needed ÷ 10 mg)
Insulin syringes (U-100, 1 mL)
One fresh syringe per administration.
- Full protocol (8 weeks)
- 40 syringes
Bacteriostatic water (10 mL bottles)
Use 3 mL per vial for reconstitution (1 × 3 mL = 3 mL).
- Full protocol (8 weeks)
- 1 × 10 mL bottle
Alcohol swabs
One for the vial stopper per draw + one for each injection site (5 days on / 2 days off). Recommend 1 × 100-count box.
- Full protocol (8 weeks)
- 80 swabs
| Supply | Full protocol (8 weeks) |
|---|---|
| Adipotide vials (10 mg each)Vials are rounded up only after calculating the whole protocol: ceil(10 ÷ 10) = 1. Usable peptide remaining in an opened vial carries forward to the next dose. | 1 vial (10 mg needed ÷ 10 mg) |
| Insulin syringes (U-100, 1 mL)One fresh syringe per administration. | 40 syringes |
| Bacteriostatic water (10 mL bottles)Use 3 mL per vial for reconstitution (1 × 3 mL = 3 mL). | 1 × 10 mL bottle |
| Alcohol swabsOne for the vial stopper per draw + one for each injection site (5 days on / 2 days off). Recommend 1 × 100-count box. | 80 swabs |
Adipotide dosage FAQs
How much bacteriostatic water do you use to reconstitute Adipotide?
Add 3.0 mL bacteriostatic water (max vial capacity) → ~3.33 mg/mL concentration. for a 10 mg Vial vial. Add the water slowly against the inside wall of the vial and swirl — never shake — until the powder fully dissolves.
What is a typical Adipotide dose?
Starting dose: 250 mcg once daily; gradual escalation by 250 mcg every 2 weeks as tolerated.. Figures are research reference values only.
How often is Adipotide administered in research protocols?
Injection frequency: Once daily — 5 days on, 2 days off (dose Mon–Fri, rest Sat–Sun).
What does the Adipotide dosing schedule look like?
Weeks 1–2 — 250 mcg — 7.5 units (0.08 mL); Weeks 3–4 — 500 mcg — 15 units (0.15 mL); Weeks 5–6 — 750 mcg — 22.5 units (0.23 mL); Weeks 7–8 — 1000 mcg (1.0 mg) — 30 units (0.30 mL). The full table above lists every step with matching syringe units.
What are the mixing steps for Adipotide?
Draw 3.0 mL bacteriostatic water with a sterile syringe. Inject slowly down the vial wall; avoid foaming. Gently swirl/roll until dissolved (do not shake).
How should reconstituted Adipotide be stored?
Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles..
How many insulin syringe units equal a Adipotide dose?
Units depend on the water volume you used. Divide your target dose by the vial concentration to get millilitres, then multiply by 100 — 1 unit on a U-100 insulin syringe is 0.01 mL. The Spartan Peptides reconstitution calculator does this conversion for you.
Is Adipotide approved for human use?
No. Adipotide is sold and referenced strictly as a research chemical. Nothing on this page is medical advice and the material is not for human consumption.
Educational and research information only. Not medical advice, not for human consumption. Values are reference figures — always verify your own math with the reconstitution calculator.
On any insulin syringe, 1 unit = 0.01 mL, so unit counts above hold across brands.